bet365亚洲官网 Receives NIH Grant to Study Reproductive Development
二零零九年十月二十四日
09-171
bet365亚洲官网 Receives NIH Grant to Study Reproductive Development
VALDOSTA -- Valdosta State University has received a $198,000
grant from the National Institutes of Health (NIH) to fund research
about the genetic mechanisms that controls the formation of the
vertebrate reproductive system.
The two-year grant titled “Mechanisms of Ovotestis Development”
will determine whether there are genetic mechanisms controlling the
formation of a mixed gonad structure referred to as an ovotestis
(having both a testis and ovary).
The research uses the fish species Kryptolebias marmoratus (Kmar)
-- commonly referred to as the mangrove killifish -- a unique
self-fertilizing hermaphroditic fish that possesses the ovotestis
再生产形式.
The genetic data generated in this study will help clarify systems
governing the 发展 of the vertebrate gonad primordial, which
is directly applicable to understanding reproductive biology.
“Our knowledge of how genetics determines sex through the
production of reproductive organs (gonads) is not complete,” said
Dr. 布莱恩·C. Ring, assistant professor of molecular genetics and
发育生物学. “It is estimated that 1 percent of the human
population has some form of intersex condition.”
Ring said the goal of this project is to perform a genetic screen
in Kmar to determine how genes are involved in ovotestis
发展.
“The hypothesis is that mutants derived from this screen will be
sterile by disrupting ovary or testis formation within the mixed
ovotestis environment,” Ring said. “By comparison of mutants to
wild-type individuals, a default mechanism is hypothesized that is
applicable to understanding the predominant bipotential of gonad
organogenesis in vertebrates.”
The information and data gathered in the research will be
applicable in understanding the 发展 of human gonad
原基.
Ring, who earned a doctorate in molecular genetics from Florida
State University, said the outcome of the project will help
researchers learn more about the genetics of this condition in the
Kmar species, which then can be applied to gaps in the knowledge of
人类生殖.
“The NIH grant will 所有ow us to learn more about the genetic
mechanism that control the formation of the vertebrate reproductive
系统,”Ring说.
Students will assist with the research on many levels. 在
initial phase, undergraduate students will focus on preparing the
fish for the genetic screen and maintaining the colonies during
发展. The second year will involve more complex scientific
tasks, including intense screening of the second and third
generations and histological examination of the mutant fish that
have reproductive defects.
“Student involvement in this research is critical for several
原因. A project like this requires many dedicated researchers
and 所有ows the students to gain valuable scientific skills,
knowledge and abilities,” Ring said. “The knowledge gained through
this research continuously builds upon what previous students
achieved, creating a perpetual for inquiry based learning by
所有.”
Ring credits prior financial and administrative support he received
from Valdosta State University in securing the NIH grant.
“bet365亚洲官网 has been very supportive at many administrative levels in
providing the support needed for me to generate preliminary data
critical in writing the NIH proposal,” Ring said.
This award is provided through the American Recovery & 救援
Act of 2009 and is the only ARRA funds awarded to Georgia’s 1st
国会选区. For more information about the ARRA, go to
http://report.nih.gov/recovery/index.aspx
Disclaimer/Acknowledgment: The Mechanisms of Ovotestis Development
is supported by award number R15HD060017 from the Eunice Kennedy
Shriver National Institute of Child Health & 人类发展.
The content is solely the responsibility of the authors and does
not necessarily represent the official views of the Eunice Kennedy
Shriver National Institute of Child Health & 人类发展
or the National Institutes of Health.
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